Description
Product Characteristics:
Plasmodium falciparum is a protozoan parasite that causes malaria. It exhibits considerable antigenic heterogeneity which may be a major problem in developing an effective vaccine against malaria. The S-antigen of Plasmodium falciparum is a highly diverse, heat stable protein that is located in the parasitophorous vacuole of the mature asexual intraerythrocytic parasite. The S-antigen gene consists of multiple alleles that originate from the same chromosome site. The amino acid sequence of each allele contains a large central section of tandemly arranged, nearly identical peptides that are specific to each allele. Thus, directed against the repeat region of a particular allele can be used to define the serotype of an S-antigen. Flanking the central repeat block are two short regions of non-repetitive sequence which occur in four different forms, each of which is utilized to define a single S-antigen family. Comparison of the four S-antigen families reveals t hat they differ considerably from each other with variation being most pronounced in the C-terminal-flanking region.
Subcellular location: Cell membrane
Synonyms: 48 kDa protein, Arrestin 1, Arrestin, ARRS_HUMAN, DKFZp686I1383, Retinal S antigen 48 KDa protein, Retinal S-antigen, Rod photoreceptor arrestin, RP47, S AG, S antigen, S antigen retina and pineal gland arrestin, S antigen retina and pineal gland, S arrestin, S-AG, S-arrestin, SAG.
Target Information: may act as a GTP/GDP-binding protein\, may play a role in signal transduction in the retina [RGD, Feb 2006]